MMP15

matrix metallopeptidase 15

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31183403 IMR-90 Human YES
31242426 HFF-2  Human YES

GO terms:

Biological Process:
cellular protein modification process [GO:0006464],
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
response to estradiol [GO:0032355],
endodermal cell differentiation [GO:0035987],
positive regulation of catalytic activity [GO:0043085],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
enzyme activator activity [GO:0008047],
zinc ion binding [GO:0008270],
metalloaminopeptidase activity [GO:0070006],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
extracellular matrix [GO:0031012],
membrane [GO:0016020],
integral component of membrane [GO:0016021],