MMP14

matrix metallopeptidase 14

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31184599 WI-38, IMR-90, HCA-2 Human YES
31242426 HFF-2  Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31653055 AGS, MCF 10A, MCF7 Human NO
25991604 Primary fibroblasts derived from mouse Heart, Kidney, Adipose, Muscle Mouse NO
31208977 CAKI-1 Human NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
angiogenesis [GO:0001525],
ovarian follicle development [GO:0001541],
response to hypoxia [GO:0001666],
endothelial cell proliferation [GO:0001935],
endochondral ossification [GO:0001958],
proteolysis [GO:0006508],
response to oxidative stress [GO:0006979],
male gonad development [GO:0008584],
response to mechanical stimulus [GO:0009612],
response to hormone [GO:0009725],
positive regulation of myotube differentiation [GO:0010831],
positive regulation of protein processing [GO:0010954],
response to organic cyclic compound [GO:0014070],
protein processing [GO:0016485],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
positive regulation of cell growth [GO:0030307],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
collagen catabolic process [GO:0030574],
zymogen activation [GO:0031638],
endodermal cell differentiation [GO:0035987],
chondrocyte proliferation [GO:0035988],
astrocyte cell migration [GO:0043615],
response to estrogen [GO:0043627],
positive regulation of B cell differentiation [GO:0045579],
negative regulation of Notch signaling pathway [GO:0045746],
embryonic cranial skeleton morphogenesis [GO:0048701],
branching morphogenesis of an epithelial tube [GO:0048754],
tissue remodeling [GO:0048771],
cell motility [GO:0048870],
negative regulation of focal adhesion assembly [GO:0051895],
head development [GO:0060322],
craniofacial suture morphogenesis [GO:0097094],
regulation of protein localization to plasma membrane [GO:1903076],
positive regulation of macrophage migration [GO:1905523],
response to odorant [GO:1990834],
ossification [GO:0001503],
cell migration [GO:0016477],
bone development [GO:0060348],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
integrin binding [GO:0005178],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
metalloaminopeptidase activity [GO:0070006],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
Golgi lumen [GO:0005796],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
focal adhesion [GO:0005925],
extracellular matrix [GO:0031012],
cytoplasmic vesicle [GO:0031410],
melanosome [GO:0042470],
macropinosome [GO:0044354],
intermediate filament cytoskeleton [GO:0045111],
membrane [GO:0016020],
integral component of membrane [GO:0016021],