ARNTL
aryl hydrocarbon receptor nuclear translocator like
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
31945054 | IMR-90 | Human | YES | |
31945125 | Primary astrocytes derived from brain | Human | YES | |
Status in senescence: Down-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
31155496 | Primary β cells derived from pancreas | Mouse | YES |
GO terms:
Biological Process:
regulation of transcription, DNA-templated [GO:0006355],
protein import into nucleus [GO:0006606],
spermatogenesis [GO:0007283],
circadian rhythm [GO:0007623],
negative regulation of TOR signaling [GO:0032007],
circadian regulation of gene expression [GO:0032922],
regulation of protein catabolic process [GO:0042176],
regulation of hair cycle [GO:0042634],
positive regulation of circadian rhythm [GO:0042753],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
negative regulation of fat cell differentiation [GO:0045599],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of neurogenesis [GO:0050767],
regulation of insulin secretion [GO:0050796],
regulation of cell cycle [GO:0051726],
response to redox state [GO:0051775],
maternal process involved in parturition [GO:0060137],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
oxidative stress-induced premature senescence [GO:0090403],
positive regulation of protein acetylation [GO:1901985],
regulation of type B pancreatic cell development [GO:2000074],
negative regulation of glucocorticoid receptor signaling pathway [GO:2000323],
regulation of cellular senescence [GO:2000772],
positive regulation of skeletal muscle cell differentiation [GO:2001016],
rhythmic process [GO:0048511],
Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
DNA binding [GO:0003677],
protein binding [GO:0005515],
aryl hydrocarbon receptor binding [GO:0017162],
bHLH transcription factor binding [GO:0043425],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
Hsp90 protein binding [GO:0051879],
repressing transcription factor binding [GO:0070491],
E-box binding [GO:0070888],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription factor binding [GO:0008134],
protein dimerization activity [GO:0046983],
Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
PML body [GO:0016605],
chromatoid body [GO:0033391],
intracellular membrane-bounded organelle [GO:0043231],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear body [GO:0016604],