MMP13

matrix metallopeptidase 13

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18516091 Adipose, Skeletal muscle Mouse NO
28401730 Primary cells derived from bone marrow, primary osteoblasts derived from bone Bone marrow Mouse NO
28728848 Primary chondrocytes derived from bone Human NO
30716534 Primary cells derived from nucleus pulposus Human NO
30773784 Primary stromal cells derived from bone marrow Mouse NO
30900385 Intervertebral disc Mouse NO
30907059 Skin, liver, kidney Mouse NO
31184599 WI-38, IMR-90, HCA-2 Human YES
31242426 HFF-2  Human YES
31823179 Primary chondrocytes derived from cartillage Rat NO
31852919 Intervertebral disc Mouse NO
31880094 Bone Mouse NO
31904537 Primary osteocytes derived from bone Mouse NO
31945054 IMR-90 Human YES
31964233 Primary mesenchymal stem cells derived from synovium Human NO

GO terms:

Biological Process:
endochondral ossification [GO:0001958],
growth plate cartilage development [GO:0003417],
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
bone mineralization [GO:0030282],
collagen catabolic process [GO:0030574],
cellular protein metabolic process [GO:0044267],
bone morphogenesis [GO:0060349],
response to beta-amyloid [GO:1904645],
heart development [GO:0007507],
response to hormone [GO:0009725],
peptide catabolic process [GO:0043171],
cartilage development [GO:0051216],
positive regulation of pancreatic trypsinogen secretion [GO:1904244],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
calcium ion binding [GO:0005509],
collagen binding [GO:0005518],
zinc ion binding [GO:0008270],
fibronectin binding [GO:0001968],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],
calcium-dependent protein binding [GO:0048306],
low-density lipoprotein particle receptor binding [GO:0050750],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
extracellular matrix [GO:0031012],
lysosome [GO:0005764],
Golgi apparatus [GO:0005794],
intercellular canaliculus [GO:0046581],