MMP12

matrix metallopeptidase 12

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30508396 Primary cells derived from muscle Human NO
30988157 IMR-90 Human YES
31182708 Primary fibroblasts derived from skin Rat NO
31184599 WI-38, IMR-90, HCA-2 Prostate, breast Human YES
31561444 Primary cells derived from pancreas Mouse NO
31904537 Primary osteocytes derived from bone Mouse NO
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES
32023351 Primary bone cells derived from bone marrow Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31542391 Plasma Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
proteolysis [GO:0006508],
protein import into nucleus [GO:0006606],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
wound healing, spreading of epidermal cells [GO:0035313],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of defense response to virus by host [GO:0050691],
positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054],
elastin catabolic process [GO:0060309],
negative regulation of type I interferon-mediated signaling pathway [GO:0060339],
positive regulation of type I interferon-mediated signaling pathway [GO:0060340],
cellular response to virus [GO:0098586],
positive regulation of interferon-alpha secretion [GO:1902741],
response to beta-amyloid [GO:1904645],
negative regulation of endothelial cell-matrix adhesion via fibronectin [GO:1904905],
positive regulation of gene expression [GO:0010628],
wound healing [GO:0042060],
regulation of trophoblast cell migration [GO:1901163],

Molecular Function:
core promoter sequence-specific DNA binding [GO:0001046],
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
calcium ion binding [GO:0005509],
collagen binding [GO:0005518],
zinc ion binding [GO:0008270],
sequence-specific DNA binding [GO:0043565],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
extracellular matrix [GO:0031012],