MMP11

matrix metallopeptidase 11

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30928680 3T3-L1 Mouse NO
31183403 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
multicellular organism development [GO:0007275],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
collagen catabolic process [GO:0030574],
negative regulation of fat cell differentiation [GO:0045599],
basement membrane organization [GO:0071711],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
Golgi lumen [GO:0005796],
extracellular matrix [GO:0031012],