ARNT2

aryl hydrocarbon receptor nuclear translocator 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30977188 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
in utero embryonic development [GO:0001701],
regulation of transcription, DNA-templated [GO:0006355],
xenobiotic metabolic process [GO:0006805],
central nervous system development [GO:0007417],
brain development [GO:0007420],
positive regulation of cell proliferation [GO:0008284],
response to estradiol [GO:0032355],
negative regulation of apoptotic process [GO:0043066],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
signal transduction [GO:0007165],
response to xenobiotic stimulus [GO:0009410],
response to toxic substance [GO:0009636],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
aryl hydrocarbon receptor binding [GO:0017162],
macromolecular complex binding [GO:0044877],
protein heterodimerization activity [GO:0046982],
DNA binding [GO:0003677],
protein dimerization activity [GO:0046983],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],