matrix metallopeptidase 10

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30977188 MSC Human YES
30988157 IMR-90 Human YES
31183403 IMR-90 Human YES
31184599 WI-38, IMR-90, HCA-2 Prostate, breast Human YES
31586152 HUVEC Human NO
31860636 2BS, 293T  Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31653055 AGS, MCF 10A, MCF7 Human NO

GO terms:

Biological Process:
proteolysis [GO:0006508],
extracellular matrix disassembly [GO:0022617],
extracellular matrix organization [GO:0030198],
collagen catabolic process [GO:0030574],
regulation of cell migration [GO:0030334],

Molecular Function:
metalloendopeptidase activity [GO:0004222],
zinc ion binding [GO:0008270],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
extracellular matrix [GO:0031012],