MME

membrane metalloendopeptidase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30977188 MSC Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
kidney development [GO:0001822],
placenta development [GO:0001890],
angiotensin maturation [GO:0002003],
proteolysis [GO:0006508],
peptide metabolic process [GO:0006518],
aging [GO:0007568],
learning or memory [GO:0007611],
sensory perception of pain [GO:0019233],
lung development [GO:0030324],
neutrophil degranulation [GO:0043312],
creatinine metabolic process [GO:0046449],
beta-amyloid metabolic process [GO:0050435],
positive regulation of neurogenesis [GO:0050769],
cellular response to cytokine stimulus [GO:0071345],
cellular response to UV-A [GO:0071492],
cellular response to UV-B [GO:0071493],
replicative senescence [GO:0090399],
beta-amyloid clearance [GO:0097242],
positive regulation of long-term synaptic potentiation [GO:1900273],

Molecular Function:
phosphatidylserine binding [GO:0001786],
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
exopeptidase activity [GO:0008238],
zinc ion binding [GO:0008270],
peptide binding [GO:0042277],
protein homodimerization activity [GO:0042803],
oligopeptidase activity [GO:0070012],
cardiolipin binding [GO:1901612],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
cytoplasm [GO:0005737],
early endosome [GO:0005769],
trans-Golgi network [GO:0005802],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
brush border [GO:0005903],
focal adhesion [GO:0005925],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
axon [GO:0030424],
dendrite [GO:0030425],
secretory granule membrane [GO:0030667],
cytoplasmic vesicle [GO:0031410],
neuronal cell body [GO:0043025],
neuron projection terminus [GO:0044306],
membrane raft [GO:0045121],
synapse [GO:0045202],
extracellular exosome [GO:0070062],
presynapse [GO:0098793],
membrane [GO:0016020],