microRNA 17

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25472717 NIH3T3, BEAS2B, Primary fibroblasts derived from cardiac tissue Heart Mouse NO

GO terms:

Biological Process:
negative regulation of systemic arterial blood pressure [GO:0003085],
outflow tract morphogenesis [GO:0003151],
negative regulation of gene expression [GO:0010629],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
negative regulation of low-density lipoprotein particle clearance [GO:0010989],
negative regulation of toll-like receptor signaling pathway [GO:0034122],
gene silencing by miRNA [GO:0035195],
miRNA mediated inhibition of translation [GO:0035278],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
positive regulation of blood pressure [GO:0045777],
positive regulation of fibroblast proliferation [GO:0048146],
positive regulation of phagocytosis [GO:0050766],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to hypoxia [GO:0071456],
positive regulation of cytokine production involved in inflammatory response [GO:1900017],
positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300],
negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109],
negative regulation of hydrogen peroxide-induced cell death [GO:1903206],
positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244],
negative regulation of sprouting angiogenesis [GO:1903671],
negative regulation of vascular endothelial growth factor production [GO:1904046],
positive regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904598],
positive regulation of metalloendopeptidase activity [GO:1904685],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
negative regulation of apoptosome assembly [GO:1905101],
positive regulation of pulmonary blood vessel remodeling [GO:1905111],
positive regulation of smooth muscle hypertrophy [GO:1905149],
negative regulation of vascular associated smooth muscle cell apoptotic process [GO:1905460],
negative regulation of cellular senescence [GO:2000773],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],
in utero embryonic development [GO:0001701],
B cell apoptotic process [GO:0001783],
pre-B cell differentiation [GO:0002329],
sensory perception of sound [GO:0007605],
response to wounding [GO:0009611],
response to bacterium [GO:0009617],
spinal cord motor neuron differentiation [GO:0021522],
lung development [GO:0030324],
cellular response to decreased oxygen levels [GO:0036294],
negative regulation of apoptotic process [GO:0043066],
long-term synaptic potentiation [GO:0060291],
ventricular septum morphogenesis [GO:0060412],
multicellular organismal iron ion homeostasis [GO:0060586],
cellular response to inorganic substance [GO:0071241],
cellular response to forskolin [GO:1904322],

Molecular Function:
mRNA binding involved in posttranscriptional gene silencing [GO:1903231],

Cellular Component:
extracellular space [GO:0005615],
mitochondrion [GO:0005739],
extracellular vesicle [GO:1903561],
RISC complex [GO:0016442],
extracellular exosome [GO:0070062],