MEF2D

myocyte enhancer factor 2D

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
osteoblast differentiation [GO:0001649],
endochondral ossification [GO:0001958],
chondrocyte differentiation [GO:0002062],
apoptotic process [GO:0006915],
nervous system development [GO:0007399],
adult heart development [GO:0007512],
muscle organ development [GO:0007517],
cell differentiation [GO:0030154],
skeletal muscle cell differentiation [GO:0035914],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
regulation of transcription, DNA-templated [GO:0006355],
multicellular organism development [GO:0007275],
positive regulation of transcription, DNA-templated [GO:0045893],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
activating transcription factor binding [GO:0033613],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
DNA binding [GO:0003677],
enzyme binding [GO:0019899],
protein dimerization activity [GO:0046983],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
intracellular membrane-bounded organelle [GO:0043231],