MEF2C

myocyte enhancer factor 2C

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
MAPK cascade [GO:0000165],
blood vessel development [GO:0001568],
osteoblast differentiation [GO:0001649],
neuron migration [GO:0001764],
B cell homeostasis [GO:0001782],
heart looping [GO:0001947],
endochondral ossification [GO:0001958],
blood vessel remodeling [GO:0001974],
chondrocyte differentiation [GO:0002062],
germinal center formation [GO:0002467],
regulation of germinal center formation [GO:0002634],
primary heart field specification [GO:0003138],
secondary heart field specification [GO:0003139],
outflow tract morphogenesis [GO:0003151],
sinoatrial valve morphogenesis [GO:0003185],
cardiac ventricle formation [GO:0003211],
regulation of transcription, DNA-templated [GO:0006355],
apoptotic process [GO:0006915],
humoral immune response [GO:0006959],
nervous system development [GO:0007399],
heart development [GO:0007507],
muscle organ development [GO:0007517],
skeletal muscle tissue development [GO:0007519],
muscle cell fate determination [GO:0007521],
learning or memory [GO:0007611],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of alkaline phosphatase activity [GO:0010694],
neural crest cell differentiation [GO:0014033],
cardiac muscle hypertrophy in response to stress [GO:0014898],
myotube differentiation [GO:0014902],
cell differentiation [GO:0030154],
neuron differentiation [GO:0030182],
platelet formation [GO:0030220],
monocyte differentiation [GO:0030224],
negative regulation of ossification [GO:0030279],
melanocyte differentiation [GO:0030318],
positive regulation of bone mineralization [GO:0030501],
positive regulation of B cell proliferation [GO:0030890],
cellular response to drug [GO:0035690],
skeletal muscle cell differentiation [GO:0035914],
cellular response to trichostatin A [GO:0035984],
B cell proliferation [GO:0042100],
regulation of neuron apoptotic process [GO:0043523],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
regulation of megakaryocyte differentiation [GO:0045652],
positive regulation of myoblast differentiation [GO:0045663],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of neurotransmitter secretion [GO:0046928],
regulation of synaptic plasticity [GO:0048167],
positive regulation of skeletal muscle tissue development [GO:0048643],
neuron development [GO:0048666],
cell morphogenesis involved in neuron differentiation [GO:0048667],
embryonic viscerocranium morphogenesis [GO:0048703],
B cell receptor signaling pathway [GO:0050853],
smooth muscle cell differentiation [GO:0051145],
positive regulation of muscle cell differentiation [GO:0051149],
regulation of synapse assembly [GO:0051963],
regulation of synaptic transmission, glutamatergic [GO:0051966],
ventricular cardiac muscle cell differentiation [GO:0055012],
palate development [GO:0060021],
regulation of synaptic activity [GO:0060025],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
excitatory postsynaptic potential [GO:0060079],
regulation of sarcomere organization [GO:0060297],
cartilage morphogenesis [GO:0060536],
regulation of dendritic spine development [GO:0060998],
renal tubule morphogenesis [GO:0061333],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to calcium ion [GO:0071277],
cellular response to parathyroid hormone stimulus [GO:0071374],
cellular response to fluid shear stress [GO:0071498],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of cell proliferation in bone marrow [GO:0071864],
glomerulus morphogenesis [GO:0072102],
nephron tubule epithelial cell differentiation [GO:0072160],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
negative regulation of vascular associated smooth muscle cell migration [GO:1904753],
negative regulation of vascular endothelial cell proliferation [GO:1905563],
positive regulation of macrophage apoptotic process [GO:2000111],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311],
positive regulation of cardiac muscle cell differentiation [GO:2000727],
positive regulation of behavioral fear response [GO:2000987],
epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013],
positive regulation of skeletal muscle cell differentiation [GO:2001016],
multicellular organism development [GO:0007275],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
cell fate commitment [GO:0045165],
embryonic skeletal system morphogenesis [GO:0048704],
negative regulation of epithelial cell proliferation [GO:0050680],
cardiac muscle cell differentiation [GO:0055007],
transdifferentiation [GO:0060290],
cellular response to retinoic acid [GO:0071300],
cellular response to growth factor stimulus [GO:0071363],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
AT DNA binding [GO:0003680],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
activating transcription factor binding [GO:0033613],
histone deacetylase binding [GO:0042826],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
HMG box domain binding [GO:0071837],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
DNA binding [GO:0003677],
protein dimerization activity [GO:0046983],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
sarcoplasm [GO:0016528],
nuclear speck [GO:0016607],
macromolecular complex [GO:0032991],
intracellular membrane-bounded organelle [GO:0043231],
postsynapse [GO:0098794],
sarcomere [GO:0030017],