MDM2

MDM2 proto-oncogene

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19132120 Salivary gland Mouse NO
27016071 Primary cells derived from lung, primary fibroblasts derived from heart Human NO
30532073 293T, U2OS, NCI-H1299, HCT 116 Human NO
30967634 HUVEC Human YES
31945125 Primary astrocytes derived from brain Human YES
32991815 Primary alveolar type II cells derived from lung Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16093429 NCI-H46 Human NO
19380490 NIH/3T3, MEF Lymph node Human, mouse NO
21678067 CCCL-1 Human NO
25067787 ACHN, A-498, Caki-2, 111, 115, 117, 154 Human NO
25382750 MKN28, KATOIII, SNU-1, SNU-16, MKN45, NCI-N87, SGC-791, AGS, MCF7, LoVo, PC-3, MRC-5, HSF Stomach, Colon Human, mouse NO
27023610 A549 Human NO
27129219 NCI-H1299, A549, Hep G2,U2OS, 293T, WI-38 Human, mouse NO
27183917 U2OS, MCF7 Human NO
29402901 HCA-2, IMR-90, WI-38 MCF 1A, 184A1a, ZR-75-1 Human NO
29523787 Human, mouse NO
30131393 Mouse NO
30920150 Primary vascular progenitor cells derived from artery Human YES
31059057 OVCA429 Human NO
31534052 Kidney Mouse NO
31973811 BRL 3A Rat NO
32030426 A549, HCT116 Human NO
33166399 MCF7 Human NO
32068317 F111 Rat NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
protein polyubiquitination [GO:0000209],
blood vessel development [GO:0001568],
blood vessel remodeling [GO:0001974],
regulation of heart rate [GO:0002027],
atrioventricular valve morphogenesis [GO:0003181],
endocardial cushion morphogenesis [GO:0003203],
ventricular septum development [GO:0003281],
atrial septum development [GO:0003283],
ubiquitin-dependent protein catabolic process [GO:0006511],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
traversing start control point of mitotic cell cycle [GO:0007089],
positive regulation of cell proliferation [GO:0008284],
response to iron ion [GO:0010039],
positive regulation of gene expression [GO:0010628],
negative regulation of protein processing [GO:0010955],
negative regulation of neuron projection development [GO:0010977],
viral process [GO:0016032],
protein ubiquitination [GO:0016567],
protein deubiquitination [GO:0016579],
protein sumoylation [GO:0016925],
peptidyl-lysine modification [GO:0018205],
protein destabilization [GO:0031648],
response to magnesium ion [GO:0032026],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
protein localization to nucleus [GO:0034504],
transcription factor catabolic process [GO:0036369],
regulation of protein catabolic process [GO:0042176],
response to cocaine [GO:0042220],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
response to morphine [GO:0043278],
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518],
establishment of protein localization [GO:0045184],
response to ether [GO:0045472],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of mitotic cell cycle [GO:0045931],
response to antibiotic [GO:0046677],
positive regulation of protein export from nucleus [GO:0046827],
response to steroid hormone [GO:0048545],
positive regulation of muscle cell differentiation [GO:0051149],
proteolysis involved in cellular protein catabolic process [GO:0051603],
protein autoubiquitination [GO:0051865],
cardiac septum morphogenesis [GO:0060411],
macromolecular complex assembly [GO:0065003],
cellular response to hydrogen peroxide [GO:0070301],
negative regulation of cell cycle arrest [GO:0071157],
cellular response to vitamin B1 [GO:0071301],
cellular response to alkaloid [GO:0071312],
cellular response to growth factor stimulus [GO:0071363],
cellular response to peptide hormone stimulus [GO:0071375],
cellular response to estrogen stimulus [GO:0071391],
cellular response to hypoxia [GO:0071456],
cellular response to gamma radiation [GO:0071480],
cellular response to UV-C [GO:0071494],
cellular response to actinomycin D [GO:0072717],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of signal transduction by p53 class mediator [GO:1901797],
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254],
response to formaldehyde [GO:1904404],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
amyloid fibril formation [GO:1990000],
response to water-immersion restraint stress [GO:1990785],
heart valve development [GO:0003170],
heart development [GO:0007507],
regulation of gene expression [GO:0010468],
negative regulation of gene expression [GO:0010629],
negative regulation of apoptotic process [GO:0043066],
positive regulation of cell cycle [GO:0045787],

Molecular Function:
p53 binding [GO:0002039],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
5S rRNA binding [GO:0008097],
zinc ion binding [GO:0008270],
ligase activity [GO:0016874],
SUMO transferase activity [GO:0019789],
enzyme binding [GO:0019899],
protein domain specific binding [GO:0019904],
ubiquitin protein ligase binding [GO:0031625],
receptor serine/threonine kinase binding [GO:0033612],
identical protein binding [GO:0042802],
peroxisome proliferator activated receptor binding [GO:0042975],
ribonucleoprotein complex binding [GO:0043021],
ubiquitin binding [GO:0043130],
protein N-terminus binding [GO:0047485],
ubiquitin protein ligase activity [GO:0061630],
NEDD8 ligase activity [GO:0061663],
scaffold protein binding [GO:0097110],
disordered domain specific binding [GO:0097718],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nuclear body [GO:0016604],
endocytic vesicle membrane [GO:0030666],
macromolecular complex [GO:0032991],
synapse [GO:0045202],