MDK

midkine

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31155234 heart heart Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
32972203 heartDPI14 vs healthy Endothelial cell Mouse NO

GO terms:

Biological Process:
behavioral fear response [GO:0001662],
leukocyte chemotaxis involved in inflammatory response [GO:0002232],
T cell activation involved in immune response [GO:0002286],
positive regulation of leukocyte chemotaxis [GO:0002690],
cytoskeleton organization [GO:0007010],
negative regulation of cell adhesion [GO:0007162],
signal transduction [GO:0007165],
Notch signaling pathway [GO:0007219],
nervous system development [GO:0007399],
short-term memory [GO:0007614],
response to wounding [GO:0009611],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of macrophage chemotaxis [GO:0010759],
positive regulation of keratinocyte proliferation [GO:0010838],
positive regulation of neuron projection development [GO:0010976],
response to auditory stimulus [GO:0010996],
dentate gyrus development [GO:0021542],
cerebellar granular layer development [GO:0021681],
cerebral cortex development [GO:0021987],
cell differentiation [GO:0030154],
negative regulation of ossification [GO:0030279],
adrenal gland development [GO:0030325],
positive regulation of cell migration [GO:0030335],
defecation [GO:0030421],
regulation of chondrocyte differentiation [GO:0032330],
tissue regeneration [GO:0042246],
response to drug [GO:0042493],
negative regulation of neuron apoptotic process [GO:0043524],
estrous cycle [GO:0044849],
positive regulation of T cell differentiation [GO:0045582],
negative regulation of regulatory T cell differentiation [GO:0045590],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription, DNA-templated [GO:0045893],
regulation of bone remodeling [GO:0046850],
oogenesis [GO:0048477],
positive regulation of oligodendrocyte differentiation [GO:0048714],
positive regulation of inflammatory response [GO:0050729],
regulation of behavior [GO:0050795],
response to glucocorticoid [GO:0051384],
positive regulation of cell division [GO:0051781],
positive regulation of cartilage development [GO:0061036],
positive regulation of smooth muscle cell chemotaxis [GO:0071673],
positive regulation of neutrophil chemotaxis [GO:0090023],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of leukocyte cell-cell adhesion [GO:1903039],
negative regulation of epithelial cell apoptotic process [GO:1904036],
positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996],
positive regulation of patterning of blood vessels [GO:1905555],
positive regulation of vascular endothelial cell proliferation [GO:1905564],
positive regulation of neural precursor cell proliferation [GO:2000179],
regulation of actin cytoskeleton reorganization [GO:2000249],
positive regulation of hepatocyte proliferation [GO:2000347],
positive regulation of neutrophil extravasation [GO:2000391],
positive regulation of interleukin-12 secretion [GO:2001184],
positive regulation of neuron migration [GO:2001224],
multicellular organism development [GO:0007275],
cell migration [GO:0016477],
hippocampus development [GO:0021766],
negative regulation of neuron death [GO:1901215],

Molecular Function:
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
chondroitin sulfate binding [GO:0035374],
heparan sulfate binding [GO:1904399],

Cellular Component:
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
cell projection [GO:0042995],