MCOLN1

mucolipin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA438 Skin, Lung Human YES
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
adaptive immune response [GO:0002250],
cation transport [GO:0006812],
calcium-mediated signaling [GO:0019722],
transferrin transport [GO:0033572],
iron ion transmembrane transport [GO:0034755],
release of sequestered calcium ion into cytosol [GO:0051209],
protein homotetramerization [GO:0051289],
calcium ion transmembrane transport [GO:0070588],
cellular response to calcium ion [GO:0071277],
cellular response to pH [GO:0071467],
autophagosome maturation [GO:0097352],
immune system process [GO:0002376],
ion transport [GO:0006811],
calcium ion transport [GO:0006816],
endosomal transport [GO:0016197],
cation transmembrane transport [GO:0098655],

Molecular Function:
cation channel activity [GO:0005261],
iron ion transmembrane transporter activity [GO:0005381],
protein binding [GO:0005515],
lipid binding [GO:0008289],
NAADP-sensitive calcium-release channel activity [GO:0072345],
intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity [GO:0097682],
ligand-gated calcium channel activity [GO:0099604],

Cellular Component:
phagocytic cup [GO:0001891],
nucleoplasm [GO:0005654],
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
late endosome [GO:0005770],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
endosome membrane [GO:0010008],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
phagocytic vesicle membrane [GO:0030670],
late endosome membrane [GO:0031902],
cell projection [GO:0042995],
intracellular membrane-bounded organelle [GO:0043231],
receptor complex [GO:0043235],
endosome [GO:0005768],
cytoplasmic vesicle [GO:0031410],
intracellular vesicle [GO:0097708],