ABL proto-oncogene 1, non-receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24177958 U2OS, HeLa, A549 Human NO

GO terms:

Biological Process:
mitotic cell cycle [GO:0000278],
neural tube closure [GO:0001843],
B-1 B cell homeostasis [GO:0001922],
positive regulation of protein phosphorylation [GO:0001934],
B cell proliferation involved in immune response [GO:0002322],
transitional one stage B cell differentiation [GO:0002333],
mismatch repair [GO:0006298],
regulation of transcription, DNA-templated [GO:0006355],
cellular protein modification process [GO:0006464],
protein phosphorylation [GO:0006468],
endocytosis [GO:0006897],
autophagy [GO:0006914],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage induced protein phosphorylation [GO:0006975],
response to oxidative stress [GO:0006979],
cell cycle arrest [GO:0007050],
epidermal growth factor receptor signaling pathway [GO:0007173],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
integrin-mediated signaling pathway [GO:0007229],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
post-embryonic development [GO:0009791],
regulation of autophagy [GO:0010506],
positive regulation of endothelial cell migration [GO:0010595],
peptidyl-tyrosine phosphorylation [GO:0018108],
cerebellum morphogenesis [GO:0021587],
negative regulation of cell-cell adhesion [GO:0022408],
microspike assembly [GO:0030035],
actin cytoskeleton organization [GO:0030036],
regulation of endocytosis [GO:0030100],
regulation of cell adhesion [GO:0030155],
negative regulation of BMP signaling pathway [GO:0030514],
regulation of axon extension [GO:0030516],
regulation of microtubule polymerization [GO:0031113],
regulation of Cdc42 protein signal transduction [GO:0032489],
regulation of actin cytoskeleton organization [GO:0032956],
positive regulation of osteoblast proliferation [GO:0033690],
substrate adhesion-dependent cell spreading [GO:0034446],
cellular response to oxidative stress [GO:0034599],
platelet-derived growth factor receptor-beta signaling pathway [GO:0035791],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
neuropilin signaling pathway [GO:0038189],
signal transduction in response to DNA damage [GO:0042770],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
endothelial cell migration [GO:0043542],
establishment of protein localization [GO:0045184],
regulation of T cell differentiation [GO:0045580],
negative regulation of mitotic cell cycle [GO:0045930],
positive regulation of mitotic cell cycle [GO:0045931],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
alpha-beta T cell differentiation [GO:0046632],
protein autophosphorylation [GO:0046777],
spleen development [GO:0048536],
thymus development [GO:0048538],
collateral sprouting [GO:0048668],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
activated T cell proliferation [GO:0050798],
T cell receptor signaling pathway [GO:0050852],
B cell receptor signaling pathway [GO:0050853],
neuromuscular process controlling balance [GO:0050885],
positive regulation of muscle cell differentiation [GO:0051149],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
positive regulation of oxidoreductase activity [GO:0051353],
negative regulation of ubiquitin-protein transferase activity [GO:0051444],
positive regulation of stress fiber assembly [GO:0051496],
mitochondrial depolarization [GO:0051882],
positive regulation of focal adhesion assembly [GO:0051894],
Bergmann glial cell differentiation [GO:0060020],
neuroepithelial cell differentiation [GO:0060563],
cellular response to hydrogen peroxide [GO:0070301],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
DNA conformation change [GO:0071103],
cellular response to lipopolysaccharide [GO:0071222],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
cardiovascular system development [GO:0072358],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
actin filament branching [GO:0090135],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
positive regulation of interleukin-2 secretion [GO:1900042],
negative regulation of long-term synaptic potentiation [GO:1900272],
negative regulation of phospholipase C activity [GO:1900275],
positive regulation of neuron death [GO:1901216],
regulation of hematopoietic stem cell differentiation [GO:1902036],
positive regulation of interferon-gamma secretion [GO:1902715],
regulation of extracellular matrix organization [GO:1903053],
cellular response to dopamine [GO:1903351],
positive regulation of microtubule binding [GO:1904528],
positive regulation of actin filament binding [GO:1904531],
regulation of modification of synaptic structure [GO:1905244],
positive regulation of patterning of blood vessels [GO:1905555],
activation of protein kinase C activity [GO:1990051],
positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096],
regulation of cell motility [GO:2000145],
regulation of actin cytoskeleton reorganization [GO:2000249],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
negative regulation of endothelial cell apoptotic process [GO:2000352],
negative regulation of cellular senescence [GO:2000773],
regulation of response to DNA damage stimulus [GO:2001020],
DNA repair [GO:0006281],
phagocytosis [GO:0006909],
apoptotic process [GO:0006915],
cell adhesion [GO:0007155],
phosphorylation [GO:0016310],
neuron differentiation [GO:0030182],
B cell proliferation [GO:0042100],
regulation of cell proliferation [GO:0042127],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
regulation of cell cycle [GO:0051726],
regulation of cellular senescence [GO:2000772],

Molecular Function:
magnesium ion binding [GO:0000287],
four-way junction DNA binding [GO:0000400],
bubble DNA binding [GO:0000405],
phosphotyrosine binding [GO:0001784],
DNA binding [GO:0003677],
transcription coactivator activity [GO:0003713],
actin monomer binding [GO:0003785],
nicotinate-nucleotide adenylyltransferase activity [GO:0004515],
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
kinase activity [GO:0016301],
SH3 domain binding [GO:0017124],
syntaxin binding [GO:0019905],
manganese ion binding [GO:0030145],
neuropilin binding [GO:0038191],
SH2 domain binding [GO:0042169],
ephrin receptor binding [GO:0046875],
actin filament binding [GO:0051015],
mitogen-activated protein kinase binding [GO:0051019],
proline-rich region binding [GO:0070064],
supercoiled DNA binding [GO:0097100],
sequence-specific double-stranded DNA binding [GO:1990837],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
metal ion binding [GO:0046872],
delta-catenin binding [GO:0070097],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
actin cytoskeleton [GO:0015629],
nuclear body [GO:0016604],
dendrite [GO:0030425],
cell leading edge [GO:0031252],
nuclear membrane [GO:0031965],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
perinuclear region of cytoplasm [GO:0048471],
postsynapse [GO:0098794],
ruffle [GO:0001726],
endoplasmic reticulum [GO:0005783],
cytoskeleton [GO:0005856],
growth cone [GO:0030426],
neuron projection [GO:0043005],
synapse [GO:0045202],