ARHGEF6

Rac/Cdc42 guanine nucleotide exchange factor 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
apoptotic process [GO:0006915],
G-protein coupled receptor signaling pathway [GO:0007186],
JNK cascade [GO:0007254],
lamellipodium assembly [GO:0030032],
positive regulation of apoptotic process [GO:0043065],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],

Cellular Component:
cytosol [GO:0005829],
lamellipodium [GO:0030027],
cell-cell junction [GO:0005911],
cell projection [GO:0042995],