MAPT

microtubule associated protein tau

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
32109515 Brain Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
microtubule cytoskeleton organization [GO:0000226],
microglial cell activation [GO:0001774],
internal protein amino acid acetylation [GO:0006475],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
cell-cell signaling [GO:0007267],
memory [GO:0007613],
response to lead ion [GO:0010288],
regulation of autophagy [GO:0010506],
negative regulation of gene expression [GO:0010629],
negative regulation of mitochondrial membrane potential [GO:0010917],
rRNA metabolic process [GO:0016072],
axonal transport of mitochondrion [GO:0019896],
central nervous system neuron development [GO:0021954],
regulation of microtubule polymerization or depolymerization [GO:0031110],
regulation of microtubule polymerization [GO:0031113],
positive regulation of microtubule polymerization [GO:0031116],
cytoplasmic microtubule organization [GO:0031122],
neuron projection development [GO:0031175],
positive regulation of superoxide anion generation [GO:0032930],
regulation of chromosome organization [GO:0033044],
negative regulation of kinase activity [GO:0033673],
stress granule assembly [GO:0034063],
cellular response to heat [GO:0034605],
cellular response to reactive oxygen species [GO:0034614],
positive regulation of axon extension [GO:0045773],
microtubule polymerization [GO:0046785],
astrocyte activation [GO:0048143],
regulation of synaptic plasticity [GO:0048167],
intracellular distribution of mitochondria [GO:0048312],
generation of neurons [GO:0048699],
synapse organization [GO:0050808],
regulation of calcium-mediated signaling [GO:0050848],
protein polymerization [GO:0051258],
axon development [GO:0061564],
regulation of microtubule cytoskeleton organization [GO:0070507],
plus-end-directed organelle transport along microtubule [GO:0072386],
regulation of mitochondrial fission [GO:0090140],
negative regulation of mitochondrial fission [GO:0090258],
fibril organization [GO:0097435],
axonal transport [GO:0098930],
regulation of cellular response to heat [GO:1900034],
regulation of long term synaptic depression [GO:1900452],
positive regulation of neuron death [GO:1901216],
positive regulation of protein localization to synapse [GO:1902474],
neurofibrillary tangle assembly [GO:1902988],
negative regulation of establishment of protein localization to mitochondrion [GO:1903748],
positive regulation of cellular protein localization [GO:1903829],
negative regulation of tubulin deacetylation [GO:1904428],
amyloid fibril formation [GO:1990000],
cellular response to nerve growth factor stimulus [GO:1990090],
cellular response to brain-derived neurotrophic factor stimulus [GO:1990416],
regulation of response to DNA damage stimulus [GO:2001020],
neuron migration [GO:0001764],
apoptotic process [GO:0006915],
axonogenesis [GO:0007409],
synapse assembly [GO:0007416],
response to nutrient [GO:0007584],
learning or memory [GO:0007611],
adult walking behavior [GO:0007628],
axo-dendritic transport [GO:0008088],
intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631],
response to organic substance [GO:0010033],
positive regulation of neuron projection development [GO:0010976],
negative regulation of intracellular transport [GO:0032387],
mitochondrion transport along microtubule [GO:0047497],
axon extension [GO:0048675],
mRNA transport [GO:0051028],
protein homooligomerization [GO:0051260],
regulation of microtubule-based movement [GO:0060632],
positive regulation of long term synaptic depression [GO:1900454],

Molecular Function:
DNA binding [GO:0003677],
AT DNA binding [GO:0003680],
double-stranded DNA binding [GO:0003690],
single-stranded DNA binding [GO:0003697],
RNA binding [GO:0003723],
actin binding [GO:0003779],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
SH3 domain binding [GO:0017124],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein binding, bridging [GO:0030674],
apolipoprotein binding [GO:0034185],
dynactin binding [GO:0034452],
phosphatidylinositol binding [GO:0035091],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],
chaperone binding [GO:0051087],
protein phosphatase 2A binding [GO:0051721],
Hsp90 protein binding [GO:0051879],
lipoprotein particle binding [GO:0071813],
histone-dependent DNA binding [GO:0099077],
microtubule lateral binding [GO:0099609],
phosphatidylinositol bisphosphate binding [GO:1902936],
tubulin binding [GO:0015631],
heat shock protein binding [GO:0031072],
macromolecular complex binding [GO:0044877],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
microtubule cytoskeleton [GO:0015630],
membrane [GO:0016020],
nuclear speck [GO:0016607],
axon [GO:0030424],
dendrite [GO:0030425],
growth cone [GO:0030426],
axolemma [GO:0030673],
nuclear periphery [GO:0034399],
cytoplasmic ribonucleoprotein granule [GO:0036464],
somatodendritic compartment [GO:0036477],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
cell body [GO:0044297],
main axon [GO:0044304],
membrane raft [GO:0045121],
tubulin complex [GO:0045298],
glial cell projection [GO:0097386],
neurofibrillary tangle [GO:0097418],
axon cytoplasm [GO:1904115],
cytoskeleton [GO:0005856],
axoneme [GO:0005930],
cytoplasmic side of plasma membrane [GO:0009898],
postsynaptic density [GO:0014069],
cell projection [GO:0042995],
axonal growth cone [GO:0044295],