MAPK3

mitogen-activated protein kinase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19164294 MEF, NIH3T3 Mouse NO
23599344 HMEC, IMR-901 Prostate gland Human NO
24291038 A549 Human NO
24937130 IMR-90, BJ, HE49 ,AT, HBEC Human NO
27443255 HeLa Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
30890431 Primary mononuclear cells derived from spleen Fish NO
31584878 A-10 Rat NO
31633821 Primary melanocytes derived from skin Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25414256 NRK-52E, WI-37 Human, rat NO
30742942 MDA-MB-231, MDA-MB-468, BT-549, SK-BR-3, MCF7, BT474 Breast Human NO
31510944 U-87 Human NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
activation of MAPK activity [GO:0000187],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of cytokine production involved in immune response [GO:0002720],
transcription initiation from RNA polymerase I promoter [GO:0006361],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
DNA damage induced protein phosphorylation [GO:0006975],
cell cycle [GO:0007049],
cell surface receptor signaling pathway [GO:0007166],
axon guidance [GO:0007411],
aging [GO:0007568],
fibroblast growth factor receptor signaling pathway [GO:0008543],
response to toxic substance [GO:0009636],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
positive regulation of macrophage chemotaxis [GO:0010759],
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066],
viral process [GO:0016032],
phosphorylation [GO:0016310],
peptidyl-serine phosphorylation [GO:0018105],
sensory perception of pain [GO:0019233],
arachidonic acid metabolic process [GO:0019369],
platelet activation [GO:0030168],
regulation of ossification [GO:0030278],
BMP signaling pathway [GO:0030509],
regulation of cellular pH [GO:0030641],
thyroid gland development [GO:0030878],
positive regulation of cyclase activity [GO:0031281],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
positive regulation of telomere maintenance via telomerase [GO:0032212],
regulation of stress-activated MAPK cascade [GO:0032872],
positive regulation of histone phosphorylation [GO:0033129],
cellular response to amino acid starvation [GO:0034198],
cellular response to reactive oxygen species [GO:0034614],
positive regulation of histone acetylation [GO:0035066],
intracellular signal transduction [GO:0035556],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-epsilon receptor signaling pathway [GO:0038095],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
outer ear morphogenesis [GO:0042473],
response to exogenous dsRNA [GO:0043330],
positive regulation of translation [GO:0045727],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
decidualization [GO:0046697],
thymus development [GO:0048538],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
cartilage development [GO:0051216],
stress-activated MAPK cascade [GO:0051403],
regulation of cytoskeleton organization [GO:0051493],
positive regulation of telomerase activity [GO:0051973],
Bergmann glial cell differentiation [GO:0060020],
face development [GO:0060324],
lung morphogenesis [GO:0060425],
trachea formation [GO:0060440],
cardiac neural crest cell development involved in heart development [GO:0061308],
macromolecular complex assembly [GO:0065003],
ERK1 and ERK2 cascade [GO:0070371],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
interleukin-1-mediated signaling pathway [GO:0070498],
response to epidermal growth factor [GO:0070849],
cellular response to mechanical stimulus [GO:0071260],
cellular response to cadmium ion [GO:0071276],
cellular response to tumor necrosis factor [GO:0071356],
caveolin-mediated endocytosis [GO:0072584],
regulation of Golgi inheritance [GO:0090170],
regulation of cellular response to heat [GO:1900034],
cellular response to dopamine [GO:1903351],
positive regulation of telomere capping [GO:1904355],
positive regulation of xenophagy [GO:1904417],
positive regulation of metallopeptidase activity [GO:1905050],
regulation of early endosome to late endosome transport [GO:2000641],
negative regulation of apolipoprotein binding [GO:2000657],
transcription, DNA-templated [GO:0006351],
cellular response to DNA damage stimulus [GO:0006974],
signal transduction [GO:0007165],
animal organ morphogenesis [GO:0009887],
neural crest cell development [GO:0014032],
response to lipopolysaccharide [GO:0032496],

Molecular Function:
phosphotyrosine binding [GO:0001784],
MAP kinase activity [GO:0004707],
MAP kinase kinase activity [GO:0004708],
protein binding [GO:0005515],
ATP binding [GO:0005524],
phosphatase binding [GO:0019902],
identical protein binding [GO:0042802],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
early endosome [GO:0005769],
late endosome [GO:0005770],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
caveola [GO:0005901],
focal adhesion [GO:0005925],
pseudopodium [GO:0031143],
macromolecular complex [GO:0032991],
membrane [GO:0016020],