mitogen-activated protein kinase 15

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
regulation of COPII vesicle coating [GO:0003400],
cellular response to DNA damage stimulus [GO:0006974],
endoplasmic reticulum organization [GO:0007029],
positive regulation of cell proliferation [GO:0008284],
regulation of gene expression [GO:0010468],
regulation of autophagy [GO:0010506],
negative regulation of cell migration [GO:0030336],
positive regulation of telomere maintenance via telomerase [GO:0032212],
intracellular signal transduction [GO:0035556],
protein autophosphorylation [GO:0046777],
positive regulation of telomerase activity [GO:0051973],
dopamine uptake [GO:0090494],
regulation of cilium assembly [GO:1902017],
positive regulation of telomere capping [GO:1904355],
protein localization to ciliary transition zone [GO:1904491],
positive regulation of metaphase/anaphase transition of meiosis I [GO:1905188],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
positive regulation of protein phosphorylation [GO:0001934],
protein phosphorylation [GO:0006468],
negative regulation of DNA replication [GO:0008156],
phosphorylation [GO:0016310],
positive regulation of protein ubiquitination [GO:0031398],
response to estradiol [GO:0032355],
positive regulation of protein catabolic process [GO:0045732],

Molecular Function:
chromatin binding [GO:0003682],
protein kinase activity [GO:0004672],
MAP kinase activity [GO:0004707],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
SH3 domain binding [GO:0017124],
nucleotide binding [GO:0000166],
protein serine/threonine kinase activity [GO:0004674],
transferase activity [GO:0016740],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
autophagosome [GO:0005776],
Golgi apparatus [GO:0005794],
centriole [GO:0005814],
cell-cell junction [GO:0005911],
bicellular tight junction [GO:0005923],
axoneme [GO:0005930],
cytoplasmic vesicle [GO:0031410],
ciliary basal body [GO:0036064],
meiotic spindle [GO:0072687],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],
cell projection [GO:0042995],