Rho guanine nucleotide exchange factor 28

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
cell differentiation [GO:0030154],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
ephrin receptor signaling pathway [GO:0048013],
central nervous system neuron axonogenesis [GO:0021955],
neurofilament cytoskeleton organization [GO:0060052],

Molecular Function:
RNA binding [GO:0003723],
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
metal ion binding [GO:0046872],
protein binding [GO:0005515],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cytoplasm [GO:0005737],
membrane [GO:0016020],