ARHGEF26

Rho guanine nucleotide exchange factor 26

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
endothelial cell morphogenesis [GO:0001886],
G-protein coupled receptor signaling pathway [GO:0007186],
positive regulation of apoptotic process [GO:0043065],
regulation of small GTPase mediated signal transduction [GO:0051056],
activation of GTPase activity [GO:0090630],
ruffle assembly [GO:0097178],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],

Cellular Component:
ruffle [GO:0001726],
cytosol [GO:0005829],
cellular_component [GO:0005575],