MAPK14

mitogen-activated protein kinase 14

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
11971971 BJ Human NO
12419465 IMR-90 Human NO
12581156 WI-38, MRC-5 Human NO
15388329 MEF Mouse NO
16864945 Endothelial progenitor cells derived from bone marrow Human NO
17882791 Primary fibroblasts derived from mouse embryo Mouse NO
18325348 IMR-90 Human NO
18830681 Primary fibroblasts derived from skin Human NO
18949386 EJ Human NO
19251701 WI-38, IMR-90, BJ Human NO
19887452 Primary chondrocytes derived from joint cartilage Rabbit NO
21050181 NCI-H46 Human NO
21187925 Endothelial progenitor cells derived from umbilical cord blood Human NO
21816217 WI-38 Human NO
22124112 PC3, DU145, HS-5, NIH 3T3, MRC5, hFOB 1.19, ALVA Prostate gland Human, mouse NO
22684553 Primary cells derived from cord blood Bone marrow Human NO
23001818 Primary fibroblasts derived from skin Human NO
23576095 WI-38 Human NO
23869868 U2OS, Saos-2, LLC, MCF7 Foreskin Human NO
23935100 Caki-1, A498, 786-O, SNU482, SNU228, A74 Human NO
24232636 Primary endothelial colony forming cell derived from the cord blood Human NO
24548645 Aorta Rat NO
24920674 A549, HUC-F2 Human NO
24934860 hMESCs Human NO
25083993 Primary CD8+T cells derived from blood Human NO
25469638 Placenta Human NO
25635535 HUVEC Human, mouse NO
25707450 Primary CD8+T cells derived from blood Human NO
26190795 Primary  chondrocytes derived from cartilage  Human NO
26992231 HUVEC Human NO
27983949 IMR-90 Human NO
30106373 Satellite cells derived from muscle Muscle Mouse NO
30693443 Cochlea Mouse NO
31160572 Human NO
31467258 Primary neurons derived from brain Mouse NO
31584878 A-10 Rat NO
31595820 MEF Mouse NO
31639393 MKN28, MKN45 Human NO
31642042 HDF Human NO
31675454 Primary mesenchymal cells derived from bone marrow Rat NO
31682715 Primary fibroblasts derived form conjuctiva Human NO
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31945054 IMR-90 Human YES
32062081 M1 macrophage Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155496 Primary β cells derived from pancreas Mouse YES

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
activation of MAPK activity [GO:0000187],
cell morphogenesis [GO:0000902],
cartilage condensation [GO:0001502],
angiogenesis [GO:0001525],
placenta development [GO:0001890],
chondrocyte differentiation [GO:0002062],
positive regulation of cytokine production involved in immune response [GO:0002720],
glucose metabolic process [GO:0006006],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
apoptotic process [GO:0006915],
chemotaxis [GO:0006935],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178],
Ras protein signal transduction [GO:0007265],
skeletal muscle tissue development [GO:0007519],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
positive regulation of macrophage chemotaxis [GO:0010759],
positive regulation of myotube differentiation [GO:0010831],
peptidyl-serine phosphorylation [GO:0018105],
fatty acid oxidation [GO:0019395],
regulation of ossification [GO:0030278],
osteoclast differentiation [GO:0030316],
positive regulation of cyclase activity [GO:0031281],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
response to muramyl dipeptide [GO:0032495],
negative regulation of hippo signaling [GO:0035331],
intracellular signal transduction [GO:0035556],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
response to muscle stretch [GO:0035994],
p38MAPK cascade [GO:0038066],
positive regulation of protein import into nucleus [GO:0042307],
signal transduction in response to DNA damage [GO:0042770],
neutrophil degranulation [GO:0043312],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of erythrocyte differentiation [GO:0045648],
positive regulation of myoblast differentiation [GO:0045663],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of glucose import [GO:0046326],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
striated muscle cell differentiation [GO:0051146],
positive regulation of muscle cell differentiation [GO:0051149],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
3'-UTR-mediated mRNA stabilization [GO:0070935],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to lipoteichoic acid [GO:0071223],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to ionizing radiation [GO:0071479],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of brown fat cell differentiation [GO:0090336],
stress-induced premature senescence [GO:0090400],
cellular response to virus [GO:0098586],
regulation of cytokine production involved in inflammatory response [GO:1900015],
positive regulation of myoblast fusion [GO:1901741],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of metallopeptidase activity [GO:1905050],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of interleukin-12 secretion [GO:2001184],
regulation of transcription, DNA-templated [GO:0006355],
protein phosphorylation [GO:0006468],
cellular response to DNA damage stimulus [GO:0006974],
myoblast differentiation involved in skeletal muscle regeneration [GO:0014835],
phosphorylation [GO:0016310],
response to lipopolysaccharide [GO:0032496],
protein autophosphorylation [GO:0046777],
stress-activated MAPK cascade [GO:0051403],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
MAP kinase activity [GO:0004707],
MAP kinase kinase activity [GO:0004708],
protein binding [GO:0005515],
ATP binding [GO:0005524],
enzyme binding [GO:0019899],
protein phosphatase binding [GO:0019903],
mitogen-activated protein kinase p38 binding [GO:0048273],
NFAT protein binding [GO:0051525],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein C-terminus binding [GO:0008022],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
spindle pole [GO:0000922],
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
nuclear speck [GO:0016607],
secretory granule lumen [GO:0034774],
glutamatergic synapse [GO:0098978],
ficolin-1-rich granule lumen [GO:1904813],