ARHGEF25

Rho guanine nucleotide exchange factor 25

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of Rho protein signal transduction [GO:0035023],
G-protein coupled receptor signaling pathway [GO:0007186],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
protein binding [GO:0005515],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
myofibril [GO:0030016],
cytosol [GO:0005829],
sarcomere [GO:0030017],