Rho/Rac guanine nucleotide exchange factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31983656 MSC Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
establishment of mitotic spindle orientation [GO:0000132],
cell morphogenesis [GO:0000902],
intracellular protein transport [GO:0006886],
actin filament organization [GO:0007015],
negative regulation of microtubule depolymerization [GO:0007026],
G-protein coupled receptor signaling pathway [GO:0007186],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of tumor necrosis factor production [GO:0032760],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
regulation of cell proliferation [GO:0042127],
positive regulation of apoptotic process [GO:0043065],
innate immune response [GO:0045087],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
negative regulation of neurogenesis [GO:0050768],
regulation of small GTPase mediated signal transduction [GO:0051056],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
asymmetric neuroblast division [GO:0055059],
negative regulation of necroptotic process [GO:0060546],
cellular response to muramyl dipeptide [GO:0071225],
cellular response to tumor necrosis factor [GO:0071356],
cellular hyperosmotic response [GO:0071474],
negative regulation of podosome assembly [GO:0071802],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219],
positive regulation of neuron migration [GO:2001224],
immune system process [GO:0002376],
cell cycle [GO:0007049],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
cell differentiation [GO:0030154],
cell division [GO:0051301],

Molecular Function:
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
Rho GTPase binding [GO:0017048],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
Rac GTPase binding [GO:0048365],
guanyl-nucleotide exchange factor activity [GO:0005085],
metal ion binding [GO:0046872],

Cellular Component:
podosome [GO:0002102],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
spindle [GO:0005819],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
bicellular tight junction [GO:0005923],
focal adhesion [GO:0005925],
cytoplasmic vesicle [GO:0031410],
vesicle [GO:0031982],
ruffle membrane [GO:0032587],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
dendritic shaft [GO:0043198],
glutamatergic synapse [GO:0098978],
postsynaptic density [GO:0014069],
cell junction [GO:0030054],