MAP4K3

mitogen-activated protein kinase kinase kinase kinase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
activation of MAPKKK activity [GO:0000185],
protein phosphorylation [GO:0006468],
JNK cascade [GO:0007254],
response to UV [GO:0009411],
response to tumor necrosis factor [GO:0034612],
intracellular signal transduction [GO:0035556],
phosphorylation [GO:0016310],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
MAP kinase kinase kinase kinase activity [GO:0008349],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
SH3 domain binding [GO:0017124],