MAP4K2

mitogen-activated protein kinase kinase kinase kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
activation of MAPKKK activity [GO:0000185],
protein phosphorylation [GO:0006468],
vesicle targeting [GO:0006903],
immune response [GO:0006955],
JNK cascade [GO:0007254],
activation of JUN kinase activity [GO:0007257],
intracellular signal transduction [GO:0035556],
innate immune response [GO:0045087],
positive regulation of JNK cascade [GO:0046330],
immune system process [GO:0002376],
phosphorylation [GO:0016310],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
MAP kinase kinase kinase kinase activity [GO:0008349],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
Golgi membrane [GO:0000139],
basolateral plasma membrane [GO:0016323],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
membrane [GO:0016020],