mitogen-activated protein kinase kinase kinase 9

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
activation of JNKK activity [GO:0007256],
activation of JUN kinase activity [GO:0007257],
positive regulation of apoptotic process [GO:0043065],
protein autophosphorylation [GO:0046777],
cell death [GO:0008219],
phosphorylation [GO:0016310],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
JUN kinase kinase kinase activity [GO:0004706],
MAP kinase kinase activity [GO:0004708],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
MAP kinase kinase kinase activity [GO:0004709],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
cellular_component [GO:0005575],