mitogen-activated protein kinase kinase kinase 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26583757 HEK293T, IMR-90, MRC-5 Kidney, Lung Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
activation of MAPKK activity [GO:0000186],
activation of MAPK activity [GO:0000187],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
positive regulation of T cell cytokine production [GO:0002726],
MyD88-dependent toll-like receptor signaling pathway [GO:0002755],
transforming growth factor beta receptor signaling pathway [GO:0007179],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
I-kappaB phosphorylation [GO:0007252],
JNK cascade [GO:0007254],
viral process [GO:0016032],
positive regulation of macroautophagy [GO:0016239],
protein deubiquitination [GO:0016579],
positive regulation of interleukin-2 production [GO:0032743],
Fc-epsilon receptor signaling pathway [GO:0038095],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
anoikis [GO:0043276],
positive regulation of JUN kinase activity [GO:0043507],
histone H3 acetylation [GO:0043966],
T cell receptor signaling pathway [GO:0050852],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
stress-activated MAPK cascade [GO:0051403],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
MAPK cascade [GO:0000165],
angiogenesis [GO:0001525],
neural tube formation [GO:0001841],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
signal transduction [GO:0007165],
phosphorylation [GO:0016310],
peptidyl-threonine phosphorylation [GO:0018107],
positive regulation of JNK cascade [GO:0046330],
negative regulation of necroptotic process [GO:0060546],
negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443],
regulation of reactive oxygen species metabolic process [GO:2000377],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
negative regulation of apoptotic signaling pathway [GO:2001234],

Molecular Function:
magnesium ion binding [GO:0000287],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase kinase kinase activity [GO:0004709],
protein binding [GO:0005515],
ATP binding [GO:0005524],
receptor tyrosine kinase binding [GO:0030971],
identical protein binding [GO:0042802],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
MAP kinase kinase activity [GO:0004708],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
IkappaB kinase complex [GO:0008385],
endosome membrane [GO:0010008],
cytoplasm [GO:0005737],
postsynaptic density [GO:0014069],
membrane [GO:0016020],