mitogen-activated protein kinase kinase kinase 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
response to ischemia [GO:0002931],
protein phosphorylation [GO:0006468],
JNK cascade [GO:0007254],
activation of JUN kinase activity [GO:0007257],
intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
viral process [GO:0016032],
cellular response to stress [GO:0033554],
cellular response to amino acid starvation [GO:0034198],
response to endoplasmic reticulum stress [GO:0034976],
p38MAPK cascade [GO:0038066],
wound healing [GO:0042060],
positive regulation of apoptotic process [GO:0043065],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
positive regulation of JUN kinase activity [GO:0043507],
innate immune response [GO:0045087],
positive regulation of myoblast differentiation [GO:0045663],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of JNK cascade [GO:0046330],
stress-activated MAPK cascade [GO:0051403],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to tumor necrosis factor [GO:0071356],
endothelial cell apoptotic process [GO:0072577],
apoptotic signaling pathway [GO:0097190],
programmed necrotic cell death [GO:0097300],
positive regulation of p38MAPK cascade [GO:1900745],
positive regulation of neuron death [GO:1901216],
cellular response to reactive nitrogen species [GO:1902170],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
activation of MAPK activity [GO:0000187],
positive regulation of protein phosphorylation [GO:0001934],
immune system process [GO:0002376],
apoptotic process [GO:0006915],
regulation of cell death [GO:0010941],
phosphorylation [GO:0016310],

Molecular Function:
magnesium ion binding [GO:0000287],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase kinase kinase activity [GO:0004709],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
protein domain specific binding [GO:0019904],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
cytosol [GO:0005829],
external side of plasma membrane [GO:0009897],
macromolecular complex [GO:0032991],
protein kinase complex [GO:1902911],
IRE1-TRAF2-ASK1 complex [GO:1990604],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],