mitogen-activated protein kinase kinase kinase 11

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
protein phosphorylation [GO:0006468],
microtubule-based process [GO:0007017],
JNK cascade [GO:0007254],
activation of JNKK activity [GO:0007256],
activation of JUN kinase activity [GO:0007257],
cell death [GO:0008219],
positive regulation of apoptotic process [GO:0043065],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of neuron apoptotic process [GO:0043525],
cell cycle G1/S phase transition [GO:0044843],
positive regulation of JNK cascade [GO:0046330],
protein autophosphorylation [GO:0046777],
phosphorylation [GO:0016310],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
JUN kinase kinase kinase activity [GO:0004706],
protein binding [GO:0005515],
ATP binding [GO:0005524],
mitogen-activated protein kinase kinase binding [GO:0031434],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
Rac GTPase binding [GO:0048365],
nucleotide binding [GO:0000166],
MAP kinase kinase kinase activity [GO:0004709],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
cytoplasm [GO:0005737],
centrosome [GO:0005813],
microtubule [GO:0005874],
membrane [GO:0016020],
cytoskeleton [GO:0005856],