mitogen-activated protein kinase kinase 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
15039780 MEF Mouse NO
31610028 Huh-7, PLC/PRF/5 Human NO
31612616 Huh-7, Hep3B Human NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
apoptotic process [GO:0006915],
response to osmotic stress [GO:0006970],
signal transduction [GO:0007165],
JNK cascade [GO:0007254],
activation of JUN kinase activity [GO:0007257],
response to heat [GO:0009408],
response to UV [GO:0009411],
peptidyl-tyrosine phosphorylation [GO:0018108],
positive regulation of telomere maintenance via telomerase [GO:0032212],
response to tumor necrosis factor [GO:0034612],
Fc-epsilon receptor signaling pathway [GO:0038095],
positive regulation of transcription, DNA-templated [GO:0045893],
stress-activated MAPK cascade [GO:0051403],
positive regulation of telomerase activity [GO:0051973],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of telomere capping [GO:1904355],
positive regulation of protein phosphorylation [GO:0001934],
protein phosphorylation [GO:0006468],
response to wounding [GO:0009611],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of JNK cascade [GO:0046330],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-1 [GO:0071347],
regulation of motor neuron apoptotic process [GO:2000671],

Molecular Function:
magnesium ion binding [GO:0000287],
MAP kinase kinase activity [GO:0004708],
protein tyrosine kinase activity [GO:0004713],
protein binding [GO:0005515],
ATP binding [GO:0005524],
JUN kinase kinase activity [GO:0008545],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
MAP kinase activity [GO:0004707],
protein C-terminus binding [GO:0008022],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],