mitogen-activated protein kinase kinase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
11971971 BJ Human NO
21137025 Primary epithelial cells derived from breast Human NO
29187894 NCI-H23, MCF1A, CSC  Human NO
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
32056555 HUVEC Human NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
peptidyl-tyrosine phosphorylation [GO:0018108],
negative regulation of hippo signaling [GO:0035331],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
p38MAPK cascade [GO:0038066],
regulation of cytokine biosynthetic process [GO:0042035],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of protein kinase activity [GO:0045860],
positive regulation of transcription, DNA-templated [GO:0045893],
cardiac muscle contraction [GO:0060048],
MAPK cascade [GO:0000165],
protein phosphorylation [GO:0006468],
phosphorylation [GO:0016310],

Molecular Function:
MAP kinase kinase activity [GO:0004708],
protein tyrosine kinase activity [GO:0004713],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
membrane [GO:0016020],