MAP2K1

mitogen-activated protein kinase kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155496 Primary β cells derived from pancreas Mouse YES
31424120 Primary cytotrophoblast cells derived from placenta Placenta Mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPK activity [GO:0000187],
protein phosphorylation [GO:0006468],
chemotaxis [GO:0006935],
cell cycle arrest [GO:0007050],
signal transduction [GO:0007165],
heart development [GO:0007507],
negative regulation of cell proliferation [GO:0008285],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
peptidyl-threonine phosphorylation [GO:0018107],
peptidyl-tyrosine phosphorylation [GO:0018108],
cerebellar cortex formation [GO:0021697],
neuron differentiation [GO:0030182],
keratinocyte differentiation [GO:0030216],
thyroid gland development [GO:0030878],
regulation of stress-activated MAPK cascade [GO:0032872],
positive regulation of transcription, DNA-templated [GO:0045893],
thymus development [GO:0048538],
regulation of axon regeneration [GO:0048679],
cell motility [GO:0048870],
positive regulation of axonogenesis [GO:0050772],
Bergmann glial cell differentiation [GO:0060020],
face development [GO:0060324],
trachea formation [GO:0060440],
epithelial cell proliferation involved in lung morphogenesis [GO:0060502],
placenta blood vessel development [GO:0060674],
labyrinthine layer development [GO:0060711],
ERK1 and ERK2 cascade [GO:0070371],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
regulation of Golgi inheritance [GO:0090170],
cellular senescence [GO:0090398],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
regulation of early endosome to late endosome transport [GO:2000641],
mitotic cell cycle [GO:0000278],
regulation of vascular smooth muscle contraction [GO:0003056],
response to oxidative stress [GO:0006979],
cell proliferation [GO:0008283],
positive regulation of autophagy [GO:0010508],
phosphorylation [GO:0016310],
positive regulation of cell migration [GO:0030335],
melanosome transport [GO:0032402],
positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968],
negative regulation of homotypic cell-cell adhesion [GO:0034111],
glucose homeostasis [GO:0042593],
positive regulation of GTPase activity [GO:0043547],
positive regulation of cell differentiation [GO:0045597],
positive regulation of muscle contraction [GO:0045933],
positive regulation of Ras protein signal transduction [GO:0046579],
vesicle transport along microtubule [GO:0047496],
Golgi inheritance [GO:0048313],
response to axon injury [GO:0048678],
neuron projection morphogenesis [GO:0048812],
response to glucocorticoid [GO:0051384],
lung morphogenesis [GO:0060425],
triglyceride homeostasis [GO:0070328],
regulation of ERK1 and ERK2 cascade [GO:0070372],
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298],
positive regulation of ATP biosynthetic process [GO:2001171],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase kinase activity [GO:0004708],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein tyrosine kinase activity [GO:0004713],
MAP-kinase scaffold activity [GO:0005078],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
protein serine/threonine kinase activator activity [GO:0043539],
protein N-terminus binding [GO:0047485],
scaffold protein binding [GO:0097110],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Ras GTPase binding [GO:0017016],
protein kinase binding [GO:0019901],
mitogen-activated protein kinase kinase kinase binding [GO:0031435],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
mitochondrion [GO:0005739],
early endosome [GO:0005769],
late endosome [GO:0005770],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
microtubule organizing center [GO:0005815],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
cell cortex [GO:0005938],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
axon [GO:0030424],
dendrite [GO:0030425],
dendrite cytoplasm [GO:0032839],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],
glutamatergic synapse [GO:0098978],