ARHGEF12
Rho guanine nucleotide exchange factor 12
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 31945054 | IMR-90 | Human | YES | |
GO terms:
Biological Process:
G-protein coupled receptor signaling pathway [GO:0007186],
Rho protein signal transduction [GO:0007266],
positive regulation of apoptotic process [GO:0043065],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],
Molecular Function:
G-protein coupled receptor binding [GO:0001664],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
guanyl-nucleotide exchange factor activity [GO:0005085],
Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],
extracellular exosome [GO:0070062],