ARHGEF10

Rho guanine nucleotide exchange factor 10

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
myelination in peripheral nervous system [GO:0022011],
actin cytoskeleton organization [GO:0030036],
regulation of Rho protein signal transduction [GO:0035023],
centrosome duplication [GO:0051298],
positive regulation of stress fiber assembly [GO:0051496],
mitotic spindle assembly [GO:0090307],
activation of GTPase activity [GO:0090630],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
protein binding [GO:0005515],
kinesin binding [GO:0019894],

Cellular Component:
centrosome [GO:0005813],
cytosol [GO:0005829],