MAP1LC3A

microtubule associated protein 1 light chain 3 alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26524528 IMR-90, MEF, HEK 293 Human NO
26942884 A375 Human NO
29548335 Saos-2 Human YES
30693443 Cochlea Mouse NO
31469660 Primary neurons derived from brain Rat NO
31481873 HT22 Mouse NO
31945125 Primary astrocytes derived from brain Human YES
33277797 Yolk Zebrafish NO
32989246 IMR90 Human NO
32466233 TIG-3 Human NO
33299530 kidney Mouse No
32802505 Primary Aortic Smooth Muscle Cells Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31158467 Primary mesangial cells derived from kidney Kidney Human, rat NO
31551807 H9c2(2-1) Rat NO
31615473 JEG-3, JAR Human NO
32047439 Primary endothelial progenitor cells isolated from bone marrow Rat NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
autophagy [GO:0006914],
cellular response to nitrogen starvation [GO:0006995],
cellular response to starvation [GO:0009267],
macroautophagy [GO:0016236],
autophagosome maturation [GO:0097352],
response to iron(II) ion [GO:0010040],
response to lead ion [GO:0010288],
cellular response to amino acid starvation [GO:0034198],
response to morphine [GO:0043278],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to copper ion [GO:0071280],

Molecular Function:
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
microtubule binding [GO:0008017],
phosphatidylethanolamine binding [GO:0008429],
ubiquitin protein ligase binding [GO:0031625],

Cellular Component:
autophagosome membrane [GO:0000421],
cytoplasm [GO:0005737],
late endosome [GO:0005770],
autophagosome [GO:0005776],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
microtubule cytoskeleton [GO:0015630],
membrane [GO:0016020],
organelle membrane [GO:0031090],
cytoplasmic vesicle [GO:0031410],
intracellular membrane-bounded organelle [GO:0043231],
autolysosome [GO:0044754],
synapse [GO:0045202],