MAP1LC3A

microtubule associated protein 1 light chain 3 alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
26524528 IMR-90, MEF, HEK 293 Human NO
26942884 A375 Human NO
29548335 Saos-2 Human YES
30693443 Cochlea Mouse NO
31469660 Primary neurons derived from brain Rat NO
31481873 HT22 Mouse NO
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31158467 Primary mesangial cells derived from kidney Kidney Human, rat NO
31551807 H9c2(2-1) Rat NO
31615473 JEG-3, JAR Human NO
32047439 Primary endothelial progenitor cells isolated from bone marrow Rat NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
autophagy [GO:0006914],
cellular response to nitrogen starvation [GO:0006995],
cellular response to starvation [GO:0009267],
macroautophagy [GO:0016236],
autophagosome maturation [GO:0097352],
response to iron(II) ion [GO:0010040],
response to lead ion [GO:0010288],
cellular response to amino acid starvation [GO:0034198],
response to morphine [GO:0043278],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to copper ion [GO:0071280],

Molecular Function:
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
microtubule binding [GO:0008017],
phosphatidylethanolamine binding [GO:0008429],
ubiquitin protein ligase binding [GO:0031625],

Cellular Component:
autophagosome membrane [GO:0000421],
cytoplasm [GO:0005737],
late endosome [GO:0005770],
autophagosome [GO:0005776],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
microtubule cytoskeleton [GO:0015630],
membrane [GO:0016020],
organelle membrane [GO:0031090],
cytoplasmic vesicle [GO:0031410],
intracellular membrane-bounded organelle [GO:0043231],
autolysosome [GO:0044754],
synapse [GO:0045202],