Rho GDP dissociation inhibitor beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
30987592 MCF7 Breast Human YES
31155496 Primary β cells derived from pancreas Mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30977188 MSC Human YES
31915373 Hheart_LA_VS healthy Smooth muscle cell Human NO

GO terms:

Biological Process:
negative regulation of cell adhesion [GO:0007162],
Rho protein signal transduction [GO:0007266],
multicellular organism development [GO:0007275],
regulation of Rho protein signal transduction [GO:0035023],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
cellular response to redox state [GO:0071461],
negative regulation of trophoblast cell migration [GO:1901164],
regulation of actin cytoskeleton reorganization [GO:2000249],

Molecular Function:
GTPase activity [GO:0003924],
Rho GDP-dissociation inhibitor activity [GO:0005094],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rac GTPase binding [GO:0048365],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
extracellular exosome [GO:0070062],