ARHGDIB
Rho GDP dissociation inhibitor beta
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Saos-2, Li-Fraumeni | Human | YES | |
| 30987592 | MCF7 | Breast | Human | YES |
| 31155496 | Primary β cells derived from pancreas | Mouse | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 30977188 | MSC | Human | YES | |
| 31915373 | Hheart_LA_VS healthy | Smooth muscle cell | Human | NO |
GO terms:
Biological Process:
negative regulation of cell adhesion [GO:0007162],
Rho protein signal transduction [GO:0007266],
multicellular organism development [GO:0007275],
regulation of Rho protein signal transduction [GO:0035023],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
cellular response to redox state [GO:0071461],
negative regulation of trophoblast cell migration [GO:1901164],
regulation of actin cytoskeleton reorganization [GO:2000249],
Molecular Function:
GTPase activity [GO:0003924],
Rho GDP-dissociation inhibitor activity [GO:0005094],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rac GTPase binding [GO:0048365],
Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
extracellular exosome [GO:0070062],