Rho GTPase activating protein 45

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
intracellular signal transduction [GO:0035556],
neutrophil degranulation [GO:0043312],
regulation of small GTPase mediated signal transduction [GO:0051056],
activation of GTPase activity [GO:0090630],
signal transduction [GO:0007165],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
cytosol [GO:0005829],
membrane [GO:0016020],
ruffle membrane [GO:0032587],
secretory granule lumen [GO:0034774],
azurophil granule lumen [GO:0035578],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
cell projection [GO:0042995],