Rho GTPase activating protein 44

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES

GO terms:

Biological Process:
exocytosis [GO:0006887],
signal transduction [GO:0007165],
regulation of actin cytoskeleton organization [GO:0032956],
regulation of Rac protein signal transduction [GO:0035020],
negative regulation of Rac protein signal transduction [GO:0035021],
regulation of GTPase activity [GO:0043087],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],
negative regulation of filopodium assembly [GO:0051490],
regulation of dendritic spine morphogenesis [GO:0061001],
modification of dendritic spine [GO:0098886],
neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887],
modification of postsynaptic structure [GO:0099010],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
Rac GTPase binding [GO:0048365],

Cellular Component:
intracellular [GO:0005622],
cytosol [GO:0005829],
postsynaptic density [GO:0014069],
dendrite [GO:0030425],
leading edge membrane [GO:0031256],
dendritic spine [GO:0043197],
presynaptic active zone [GO:0048786],
recycling endosome [GO:0055037],
glutamatergic synapse [GO:0098978],
cytoplasm [GO:0005737],
endosome [GO:0005768],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],