MACF1

microtubule actin crosslinking factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
mesoderm formation [GO:0001707],
posttranslational protein targeting to membrane [GO:0006620],
movement of cell or subcellular component [GO:0006928],
cytoskeleton organization [GO:0007010],
establishment or maintenance of cell polarity [GO:0007163],
protein localization [GO:0008104],
regulation of epithelial cell migration [GO:0010632],
Wnt signaling pathway [GO:0016055],
positive regulation of Wnt signaling pathway [GO:0030177],
regulation of microtubule-based process [GO:0032886],
wound healing [GO:0042060],
intermediate filament cytoskeleton organization [GO:0045104],
regulation of focal adhesion assembly [GO:0051893],
regulation of cell migration [GO:0030334],
Golgi to plasma membrane protein transport [GO:0043001],
positive regulation of axon extension [GO:0045773],

Molecular Function:
actin binding [GO:0003779],
structural molecule activity [GO:0005198],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
cytoskeletal protein binding [GO:0008092],
ATPase activity [GO:0016887],
metal ion binding [GO:0046872],
RNA binding [GO:0003723],
cadherin binding [GO:0045296],
microtubule minus-end binding [GO:0051011],
actin filament binding [GO:0051015],

Cellular Component:
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
intermediate filament [GO:0005882],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
postsynaptic density [GO:0014069],
actin cytoskeleton [GO:0015629],
microtubule cytoskeleton [GO:0015630],
membrane [GO:0016020],
cell projection [GO:0042995],
ruffle membrane [GO:0032587],