LTA4H

leukotriene A4 hydrolase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31687975 IMR-90 Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
leukotriene metabolic process [GO:0006691],
leukotriene biosynthetic process [GO:0019370],
long-chain fatty acid biosynthetic process [GO:0042759],
peptide catabolic process [GO:0043171],
neutrophil degranulation [GO:0043312],
cellular lipid metabolic process [GO:0044255],
cellular protein metabolic process [GO:0044267],

Molecular Function:
RNA binding [GO:0003723],
aminopeptidase activity [GO:0004177],
epoxide hydrolase activity [GO:0004301],
leukotriene-A4 hydrolase activity [GO:0004463],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
zinc ion binding [GO:0008270],
metalloaminopeptidase activity [GO:0070006],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],
tertiary granule lumen [GO:1904724],
ficolin-1-rich granule lumen [GO:1904813],
cytoplasm [GO:0005737],