LRRK2

leucine rich repeat kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
activation of MAPK activity [GO:0000187],
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of protein phosphorylation [GO:0001934],
protein phosphorylation [GO:0006468],
protein import into nucleus [GO:0006606],
endocytosis [GO:0006897],
autophagy [GO:0006914],
response to oxidative stress [GO:0006979],
mitochondrion organization [GO:0007005],
endoplasmic reticulum organization [GO:0007029],
Golgi organization [GO:0007030],
lysosome organization [GO:0007040],
signal transduction [GO:0007165],
neuromuscular junction development [GO:0007528],
determination of adult lifespan [GO:0008340],
cellular response to starvation [GO:0009267],
regulation of gene expression [GO:0010468],
regulation of autophagy [GO:0010506],
positive regulation of autophagy [GO:0010508],
regulation of protein kinase A signaling [GO:0010738],
negative regulation of protein processing [GO:0010955],
negative regulation of neuron projection development [GO:0010977],
regulation of neuron maturation [GO:0014041],
negative regulation of macroautophagy [GO:0016242],
phosphorylation [GO:0016310],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
calcium-mediated signaling [GO:0019722],
olfactory bulb development [GO:0021772],
tangential migration from the subventricular zone to the olfactory bulb [GO:0022028],
cell differentiation [GO:0030154],
positive regulation of protein ubiquitination [GO:0031398],
regulation of protein stability [GO:0031647],
negative regulation of protein binding [GO:0032091],
positive regulation of protein binding [GO:0032092],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
negative regulation of GTPase activity [GO:0034260],
cellular response to oxidative stress [GO:0034599],
cellular protein localization [GO:0034613],
intracellular signal transduction [GO:0035556],
regulation of kidney size [GO:0035564],
exploration behavior [GO:0035640],
locomotory exploration behavior [GO:0035641],
regulation of lysosomal lumen pH [GO:0035751],
synaptic vesicle recycling [GO:0036465],
regulation of locomotion [GO:0040012],
regulation of membrane potential [GO:0042391],
positive regulation of programmed cell death [GO:0043068],
GTP metabolic process [GO:0046039],
protein autophosphorylation [GO:0046777],
intracellular distribution of mitochondria [GO:0048312],
neuron projection morphogenesis [GO:0048812],
mitochondrion localization [GO:0051646],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
regulation of mitochondrial depolarization [GO:0051900],
regulation of synaptic transmission, glutamatergic [GO:0051966],
excitatory postsynaptic potential [GO:0060079],
regulation of dopamine receptor signaling pathway [GO:0060159],
positive regulation of dopamine receptor signaling pathway [GO:0060161],
regulation of ER to Golgi vesicle-mediated transport [GO:0060628],
regulation of canonical Wnt signaling pathway [GO:0060828],
regulation of dendritic spine morphogenesis [GO:0061001],
protein localization to endoplasmic reticulum exit site [GO:0070973],
neuron death [GO:0070997],
cellular response to manganese ion [GO:0071287],
cellular response to organic cyclic compound [GO:0071407],
reactive oxygen species metabolic process [GO:0072593],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
negative regulation of excitatory postsynaptic potential [GO:0090394],
regulation of synaptic vesicle endocytosis [GO:1900242],
positive regulation of synaptic vesicle endocytosis [GO:1900244],
regulation of neuron death [GO:1901214],
negative regulation of neuron death [GO:1901215],
positive regulation of histone deacetylase activity [GO:1901727],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
positive regulation of protein autoubiquitination [GO:1902499],
regulation of neuroblast proliferation [GO:1902692],
regulation of synaptic vesicle transport [GO:1902803],
negative regulation of autophagosome assembly [GO:1902902],
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125],
negative regulation of hydrogen peroxide-induced cell death [GO:1903206],
negative regulation of protein targeting to mitochondrion [GO:1903215],
cellular response to dopamine [GO:1903351],
positive regulation of microglial cell activation [GO:1903980],
positive regulation of tumor necrosis factor secretion [GO:1904469],
Wnt signalosome assembly [GO:1904887],
regulation of retrograde transport, endosome to Golgi [GO:1905279],
regulation of CAMKK-AMPK signaling cascade [GO:1905289],
regulation of branching morphogenesis of a nerve [GO:2000172],
regulation of synaptic vesicle exocytosis [GO:2000300],
spermatogenesis [GO:0007283],
striatum development [GO:0021756],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of GTPase activity [GO:0043547],
canonical Wnt signaling pathway [GO:0060070],
protein localization to mitochondrion [GO:0070585],
regulation of mitochondrial fission [GO:0090140],
negative regulation of late endosome to lysosome transport [GO:1902823],
negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217],

Molecular Function:
SNARE binding [GO:0000149],
nucleotide binding [GO:0000166],
magnesium ion binding [GO:0000287],
actin binding [GO:0003779],
GTPase activity [GO:0003924],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase kinase activity [GO:0004708],
protein serine/threonine phosphatase activity [GO:0004722],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
ATP binding [GO:0005524],
GTP binding [GO:0005525],
tubulin binding [GO:0015631],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
hydrolase activity [GO:0016787],
Rho GTPase binding [GO:0017048],
syntaxin-1 binding [GO:0017075],
receptor signaling complex scaffold activity [GO:0030159],
clathrin binding [GO:0030276],
GTP-dependent protein kinase activity [GO:0034211],
peroxidase inhibitor activity [GO:0036479],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ion channel binding [GO:0044325],
macromolecular complex binding [GO:0044877],
protein kinase A binding [GO:0051018],
beta-catenin destruction complex binding [GO:1904713],
microtubule binding [GO:0008017],
co-receptor binding [GO:0039706],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial inner membrane [GO:0005743],
mitochondrial matrix [GO:0005759],
lysosome [GO:0005764],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
Golgi-associated vesicle [GO:0005798],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
synaptic vesicle [GO:0008021],
membrane [GO:0016020],
inclusion body [GO:0016234],
cell junction [GO:0030054],
axon [GO:0030424],
dendrite [GO:0030425],
growth cone [GO:0030426],
cytoplasmic vesicle [GO:0031410],
mitochondrial membrane [GO:0031966],
cytoplasmic side of mitochondrial outer membrane [GO:0032473],
dendrite cytoplasm [GO:0032839],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
terminal bouton [GO:0043195],
perikaryon [GO:0043204],
intracellular membrane-bounded organelle [GO:0043231],
amphisome [GO:0044753],
autolysosome [GO:0044754],
membrane raft [GO:0045121],
synapse [GO:0045202],
endoplasmic reticulum exit site [GO:0070971],
multivesicular body, internal vesicle [GO:0097487],
glutamatergic synapse [GO:0098978],
caveola neck [GO:0099400],
presynaptic cytosol [GO:0099523],
ribonucleoprotein complex [GO:1990904],
Wnt signalosome [GO:1990909],
Golgi membrane [GO:0000139],
extracellular space [GO:0005615],
endoplasmic reticulum membrane [GO:0005789],
synaptic vesicle membrane [GO:0030672],
extracellular exosome [GO:0070062],
postsynapse [GO:0098794],