LDL receptor related protein associated protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of receptor internalization [GO:0002091],
signal transduction [GO:0007165],
negative regulation of very-low-density lipoprotein particle clearance [GO:0010916],
negative regulation of protein binding [GO:0032091],
regulation of receptor-mediated endocytosis [GO:0048259],
negative regulation of cell death [GO:0060548],
extracellular negative regulation of signal transduction [GO:1900116],
negative regulation of beta-amyloid clearance [GO:1900222],
positive regulation of beta-amyloid clearance [GO:1900223],
negative regulation of receptor activity [GO:2000272],

Molecular Function:
beta-amyloid binding [GO:0001540],
receptor binding [GO:0005102],
protein binding [GO:0005515],
heparin binding [GO:0008201],
lipase binding [GO:0035473],
receptor agonist activity [GO:0048018],
receptor antagonist activity [GO:0048019],
low-density lipoprotein particle receptor binding [GO:0050750],
very-low-density lipoprotein particle receptor binding [GO:0070326],

Cellular Component:
extracellular region [GO:0005576],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum-Golgi intermediate compartment [GO:0005793],
Golgi apparatus [GO:0005794],
Golgi lumen [GO:0005796],
cis-Golgi network [GO:0005801],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
endomembrane system [GO:0012505],
endosome lumen [GO:0031904],
rough endoplasmic reticulum lumen [GO:0048237],
cytoplasm [GO:0005737],
rough endoplasmic reticulum [GO:0005791],
vesicle [GO:0031982],