LRP8

LDL receptor related protein 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
proteolysis [GO:0006508],
lipid metabolic process [GO:0006629],
endocytosis [GO:0006897],
signal transduction [GO:0007165],
cytokine-mediated signaling pathway [GO:0019221],
ammon gyrus development [GO:0021541],
cerebral cortex development [GO:0021987],
positive regulation of CREB transcription factor activity [GO:0032793],
reelin-mediated signaling pathway [GO:0038026],
response to drug [GO:0042493],
regulation of apoptotic process [GO:0042981],
regulation of innate immune response [GO:0045088],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
modulation of synaptic transmission [GO:0050804],
positive regulation of dendritic spine morphogenesis [GO:0061003],
positive regulation of protein tyrosine kinase activity [GO:0061098],
cellular response to growth factor stimulus [GO:0071363],
cellular response to cholesterol [GO:0071397],
positive regulation of dendrite development [GO:1900006],
chemical synaptic transmission [GO:0007268],
ventral spinal cord development [GO:0021517],
hippocampus development [GO:0021766],
layer formation in cerebral cortex [GO:0021819],
positive regulation of protein kinase activity [GO:0045860],
dendrite morphogenesis [GO:0048813],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
low-density lipoprotein receptor activity [GO:0005041],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
high-density lipoprotein particle binding [GO:0008035],
kinesin binding [GO:0019894],
very-low-density lipoprotein particle receptor activity [GO:0030229],
apolipoprotein binding [GO:0034185],
cargo receptor activity [GO:0038024],
reelin receptor activity [GO:0038025],
beta-amyloid binding [GO:0001540],
protein N-terminus binding [GO:0047485],
calcium-dependent protein binding [GO:0048306],

Cellular Component:
extracellular region [GO:0005576],
microtubule associated complex [GO:0005875],
plasma membrane [GO:0005886],
caveola [GO:0005901],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
dendrite [GO:0030425],
neuronal cell body [GO:0043025],
receptor complex [GO:0043235],
extracellular space [GO:0005615],
cell surface [GO:0009986],