LRP1

LDL receptor related protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25799988 IMR-90 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
astrocyte activation involved in immune response [GO:0002265],
lipid metabolic process [GO:0006629],
receptor-mediated endocytosis [GO:0006898],
phagocytosis [GO:0006909],
lysosomal transport [GO:0007041],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205],
aging [GO:0007568],
cell proliferation [GO:0008283],
regulation of extracellular matrix disassembly [GO:0010715],
positive regulation of cholesterol efflux [GO:0010875],
positive regulation of cell death [GO:0010942],
negative regulation of neuron projection development [GO:0010977],
negative regulation of smooth muscle cell migration [GO:0014912],
cerebral cortex development [GO:0021987],
negative regulation of Wnt signaling pathway [GO:0030178],
receptor internalization [GO:0031623],
positive regulation of protein binding [GO:0032092],
positive regulation of lipid transport [GO:0032370],
regulation of cholesterol transport [GO:0032374],
regulation of phospholipase A2 activity [GO:0032429],
regulation of actin cytoskeleton organization [GO:0032956],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
aorta morphogenesis [GO:0035909],
lipoprotein metabolic process [GO:0042157],
lipoprotein transport [GO:0042953],
apoptotic cell clearance [GO:0043277],
negative regulation of neuron apoptotic process [GO:0043524],
cellular lipid catabolic process [GO:0044242],
transcytosis [GO:0045056],
positive regulation of endocytosis [GO:0045807],
positive regulation of axon extension involved in regeneration [GO:0048691],
positive regulation of collateral sprouting of injured axon [GO:0048694],
positive regulation of phagocytosis [GO:0050766],
negative regulation of cytosolic calcium ion concentration [GO:0051481],
negative regulation of focal adhesion assembly [GO:0051895],
chemoattraction of axon [GO:0061642],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
beta-amyloid clearance [GO:0097242],
positive regulation of Schwann cell migration [GO:1900149],
positive regulation of beta-amyloid clearance [GO:1900223],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of cholesterol import [GO:1904109],
positive regulation of transcytosis [GO:1904300],
cellular response to beta-amyloid [GO:1904646],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
negative regulation of metallopeptidase activity [GO:1905049],
positive regulation of lysosomal protein catabolic process [GO:1905167],
positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343],
negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587],
cardiac septum development [GO:0003279],
endocytosis [GO:0006897],
multicellular organism development [GO:0007275],
cholesterol metabolic process [GO:0008203],
negative regulation of cell-substrate adhesion [GO:0010812],
positive regulation of neuron projection development [GO:0010976],
negative regulation of apoptotic process [GO:0043066],
positive regulation of axon extension [GO:0045773],
positive regulation of protein transport [GO:0051222],
negative regulation of cell death [GO:0060548],
coronary vasculature development [GO:0060976],

Molecular Function:
beta-amyloid binding [GO:0001540],
protease binding [GO:0002020],
RNA binding [GO:0003723],
low-density lipoprotein receptor activity [GO:0005041],
scavenger receptor activity [GO:0005044],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
coreceptor activity [GO:0015026],
alpha-2 macroglobulin receptor activity [GO:0016964],
apolipoprotein receptor activity [GO:0030226],
clathrin heavy chain binding [GO:0032050],
apolipoprotein binding [GO:0034185],
signaling receptor activity [GO:0038023],
cargo receptor activity [GO:0038024],
heparan sulfate proteoglycan binding [GO:0043395],
macromolecular complex binding [GO:0044877],
lipoprotein particle receptor binding [GO:0070325],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
lysosomal membrane [GO:0005765],
early endosome [GO:0005769],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
clathrin-coated pit [GO:0005905],
focal adhesion [GO:0005925],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
clathrin-coated vesicle [GO:0030136],
dendrite [GO:0030425],
endocytic vesicle membrane [GO:0030666],
insulin-responsive compartment [GO:0032593],
neuronal cell body [GO:0043025],
receptor complex [GO:0043235],
axonal growth cone [GO:0044295],
apical part of cell [GO:0045177],
plasma membrane protein complex [GO:0098797],
cytoplasm [GO:0005737],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],