LOX

lysyl oxidase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24113189 Primary mammary epithelial cells derived from brain Pancreas Human, mouse NO
33296652 heart heart Human NO
32972203 heartDPI7 vs healthy Endothelial cell,Brush cell (Tuft cell),Ciliated cell Mouse NO
32972203 heartDPI14 vs healthy Endothelial cell Mouse NO

GO terms:

Biological Process:
osteoblast differentiation [GO:0001649],
regulation of protein phosphorylation [GO:0001932],
cellular protein modification process [GO:0006464],
heart development [GO:0007507],
regulation of gene expression [GO:0010468],
regulation of striated muscle tissue development [GO:0016202],
regulation of transforming growth factor beta receptor signaling pathway [GO:0017015],
peptidyl-lysine oxidation [GO:0018057],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
bone mineralization [GO:0030282],
lung development [GO:0030324],
platelet-derived growth factor receptor-beta signaling pathway [GO:0035791],
ascending aorta development [GO:0035905],
descending aorta development [GO:0035906],
wound healing [GO:0042060],
response to drug [GO:0042493],
regulation of apoptotic process [GO:0042981],
protein kinase B signaling [GO:0043491],
regulation of megakaryocyte differentiation [GO:0045652],
muscle cell cellular homeostasis [GO:0046716],
elastic fiber assembly [GO:0048251],
blood vessel morphogenesis [GO:0048514],
response to steroid hormone [GO:0048545],
muscle fiber development [GO:0048747],
cell chemotaxis [GO:0060326],
connective tissue development [GO:0061448],
DNA biosynthetic process [GO:0071897],
regulation of receptor binding [GO:1900120],
regulation of bone development [GO:1903010],
cellular response to chemokine [GO:1990869],
regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000586],
blood vessel development [GO:0001568],
response to hormone [GO:0009725],
protein oxidation [GO:0018158],
aorta development [GO:0035904],
oxidation-reduction process [GO:0055114],
cellular response to organic substance [GO:0071310],

Molecular Function:
protein-lysine 6-oxidase activity [GO:0004720],
copper ion binding [GO:0005507],
protein binding [GO:0005515],
collagen binding [GO:0005518],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [GO:0016641],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
collagen trimer [GO:0005581],
extracellular space [GO:0005615],
nucleus [GO:0005634],
extracellular matrix [GO:0031012],