Rho GTPase activating protein 17

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA517 Skin, Lung Human YES

GO terms:

Biological Process:
actin filament organization [GO:0007015],
signal transduction [GO:0007165],
calcium ion regulated exocytosis [GO:0017156],
regulation of actin cytoskeleton organization [GO:0032956],
regulation of Rac protein signal transduction [GO:0035020],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
SH3 domain binding [GO:0017124],
Rac GTPase binding [GO:0048365],

Cellular Component:
intracellular [GO:0005622],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
bicellular tight junction [GO:0005923],
cytoplasm [GO:0005737],
membrane [GO:0016020],
cell junction [GO:0030054],