leucyl and cystinyl aminopeptidase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480],
proteolysis [GO:0006508],
cell-cell signaling [GO:0007267],
female pregnancy [GO:0007565],
protein catabolic process [GO:0030163],
peptide catabolic process [GO:0043171],
SMAD protein signal transduction [GO:0060395],

Molecular Function:
aminopeptidase activity [GO:0004177],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
peptide binding [GO:0042277],
metalloaminopeptidase activity [GO:0070006],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
lysosomal membrane [GO:0005765],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
cytoplasmic vesicle membrane [GO:0030659],
early endosome lumen [GO:0031905],
perinuclear region of cytoplasm [GO:0048471],
integral component of membrane [GO:0016021],