LLGL scribble cell polarity complex component 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
exocytosis [GO:0006887],
Golgi to plasma membrane transport [GO:0006893],
axonogenesis [GO:0007409],
regulation of Notch signaling pathway [GO:0008593],
cortical actin cytoskeleton organization [GO:0030866],
regulation of establishment or maintenance of cell polarity [GO:0032878],
positive regulation of GTPase activity [GO:0043547],
regulation of protein secretion [GO:0050708],
establishment of spindle orientation [GO:0051294],
macromolecular complex assembly [GO:0065003],
brain development [GO:0007420],
maintenance of apical/basal cell polarity [GO:0035090],

Molecular Function:
GTPase activator activity [GO:0005096],
structural molecule activity [GO:0005198],
protein binding [GO:0005515],
Rab GTPase binding [GO:0017137],
protein kinase binding [GO:0019901],
myosin II binding [GO:0045159],

Cellular Component:
Golgi cis cisterna [GO:0000137],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
axon [GO:0030424],
cortical actin cytoskeleton [GO:0030864],
early endosome membrane [GO:0031901],
trans-Golgi network membrane [GO:0032588],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
myelin sheath abaxonal region [GO:0035748],
cell projection [GO:0042995],